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Approximately one-fourth of the population in the Western world develops or dies from some form of cancer. In this monograph two hundred fifty extensive tabulations document cancer mortality in the United States during 1959–1961, encompassing a wider range of demographic variables than usual, including age, sex, race, marital status, geographic distribution, urban and socioeconomic status, and country of origin. The most striking demographic association of cancer is with age. The authors offer suggestions for further analyses and state the need for developing a “national bookkeeping” system to monitor mortality trends.