The advent of chemical or pharmacological therapies has had an enormous impact on the treatment of psychiatric illness. For the chemotherapy to be effective, however, the clinician must take into account many factors in addition to recognition of a syndrome and selection of an appropriate agent and dose. In this extensively revised and expanded edition of a widely used book, Ross Baldessarini concentrates on providing rational, scientific underpinnings for the treatment of patients. In doing so, he bridges the gap between biology, psychology, and clinical practice.

To provide the most up-to-date coverage of the actions and use of psychotropic agents, Professor Baldessarini has enlarged the text to nearly twice its original length and has added sixty-three new tables. More basic preclinical pharmacology is included to guide the thoughtful use of medication. In addition to summarizing this basic knowledge, the text reviews the indications for each drug, the kinds of patients most likely to respond, and side effects and contraindications, and provides summaries of clinical research findings on which rational clinical practice rests.

A chapter is devoted to each of the principal classes of psychotropic drugs: antipsychotic agents, lithium salts and other antimanic agents, antidepressant agents, and antianxiety drugs. Within each chapter is a new section that surveys the future of the field and examines new procedures, theories, and agents. A final chapter covers more general topics such as psychosocial, ethical, and legal aspects of practice in the administration of drugs, as well as the emerging topics of geriatric and pediatric psychopharmacology--material not readily available elsewhere.