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The Generation of Diversity

The Generation of Diversity

Clonal Selection Theory and the Rise of Molecular Immunology

Alfred I. Tauber, Scott H. Podolsky

ISBN 9780674001824

Publication date: 04/25/2000

In recent decades immunology has been one of the most exciting--and successful--fields of biomedical research. Over the past thirty years immunologists have acquired a detailed understanding of the immune system's unique recognition mechanism and of the cellular and chemical means used to destroy or neutralize invading organisms. This understanding has been formulated in terms of the clonal selection theory, the dominant explanation of immune behavior. That story is the subject of The Generation of Diversity.

A major problem for immunologists had long been to determine how cells of the immune system could produce millions of distinct antibodies--and produce them on demand. The clonal selection theory explains that cells with genetic instructions to produce each antibody exist in the body in small numbers until exposure to the right molecule--the antigen--triggers the selective cloning that will reproduce exactly the cell needed. But how can so many different antibody-producing cells be generated from such limited genetic material? The solution to this question came from new applications of molecular biology, and, as the authors argue, the impact of the new techniques changed both the methods and the concepts of immunology.

The Generation of Diversity is an intellectual history of the major theoretical problem in immunology and its resolution in the post-World War II period. It will provide for immunologists essential background for understanding the conceptual conflicts occurring in the field today.


  • Scott Podolsky and Alfred Tauber have written a dense and exhaustive scholarly treatise about the history of [the generation of diversity]. They explore the intellectual setting in which the Tonegawa experiment was performed by reviewing original literature and interviewing the major actors in the drama...Everyone interested in the history of immunology and genetics should read this book.

    —Fred S. Rosen, Nature


  • Alfred I. Tauber is Professor of Medicine and Philosophy and Director at the Center for Philosophy and History of Science, Boston University. He is the author of The Immune Self: Theory or Metaphor? and coauthor of Metchnikoff and the Origins of Immunology.
  • Scott H. Podolsky is a First-Year Resident in Medicine at Brigham and Women's Hospital in Boston.

Book Details

  • 528 pages
  • 5-7/8 x 8-15/16 inches
  • Harvard University Press