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The Society of Genes

The Society of Genes

Itai Yanai, Martin Lercher

ISBN 9780674425026

Publication date: 01/11/2016

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Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The Society of Genes now provides a vision of how genes cooperate and compete in the struggle for life.

Pioneers in the nascent field of systems biology, Itai Yanai and Martin Lercher present a compelling new framework to understand how the human genome evolved and why understanding the interactions among our genes shifts the basic paradigm of modern biology. Contrary to what Dawkins’s popular metaphor seems to imply, the genome is not made of individual genes that focus solely on their own survival. Instead, our genomes comprise a society of genes which, like human societies, is composed of members that form alliances and rivalries.

In language accessible to lay readers, The Society of Genes uncovers genetic strategies of cooperation and competition at biological scales ranging from individual cells to entire species. It captures the way the genome works in cancer cells and Neanderthals, in sexual reproduction and the origin of life, always underscoring one critical point: that only by putting the interactions among genes at center stage can we appreciate the logic of life.

Praise

  • Yanai and Lercher invite the reader to step back and observe how genes assemble together to make a global genetic system, or genome… [It] largely succeeds in translating the findings of an esoteric science into something that is easily understood… The Society of Genes represents a timely and welcome handbook for navigating this postgenomic era.

    —Joseph Swift, Science

Authors

  • Itai Yanai is Associate Professor of Biology at the Technion–Israel Institute of Technology and a Fellow at the Radcliffe Institute for Advanced Studies at Harvard University.
  • Martin Lercher is Professor of Bioinformatics at Heinrich Heine University, Düsseldorf.

Book Details

  • 296 pages
  • 5-1/2 x 8-1/4 inches
  • Harvard University Press

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