Cocaine Addiction

Preface
I. History, Use, and Pharmacology
- 1. The Problem of Cocaine Abuse and Addiction
  - A Brief History of Erythroxylon coca
  - Cocaine Use and Users in the United States: An Overview
  - The Cost of Cocaine Abuse
  - Entering Treatment
  - Conclusions
- 2. Administration, Action, and Pharmacology of Cocaine
  - What Is Cocaine?
  - Forms of Cocaine
  - Administration and Actions
  - Purity of Illicit Cocaine
  - Latency and Duration of Action
  - The Neurobiology of Cocaine
  - Use of Cocaine with Other Drugs
  - Conclusions
II. Behavioral Aspects
- 3. The Subjective Experience, Course, and Parameters of Cocaine Abuse
  - Subjective and Related Effects
  - Is Cocaine Addicting?
  - The Course of Addiction
  - Tolerance
  - Symptoms of Abstinence
  - Theoretical Explanations of Cocaine Abuse
  - Conclusions
- 4. Characteristics and Behavioral Patterns of Cocaine Abusers
  - Personal Characteristics
  - Variables Contributing to the Development of Cocaine Abuse
  - Cocaine Abuse and Crime
  - Usefulness of Self-Reports of Cocaine Abuse
  - Conclusions
III. Psychopathological and Medical Aspects
- 5. Cocaine Abuse, Psychopathology, and Personality Disorders
  - Psychopathology
  - Clinical (AXIS I) Disorders
  - Personality (AXIS II) Disorders
  - Psychopathology in Cocaine Abusers versus Abusers of Other Drugs
  - Cocaine and Other Substance Abuse in Psychiatric Patients
  - Direct Psychiatric Complications of Cocaine Abuse
  - Effects of Cocaine Abuse on Memory and Cognition
  - Conclusions
- 6. Medical and Related Consequences of Cocaine Abuse
  - Presentation of Cocaine-Related Medical Problems
  - Specific Systematic Complications
  - Respiratory System
  - Gastrointestinal System
  - Genitourinary System
  - Obstetrical and Neonatal Complications
  - Immune System
  - Acute Complications
  - Complications of Injection Use of Drugs
  - Chronic Complications
  - Cocaine-Related Mortality
  - Conclusions
- 7. Cocaine Abuse and Sexual Behavior
  - Sexual Functioning
  - Compulsive Sexuality and the Treatment Process
  - Cocaine and the Spread of Sexually Transmitted Diseases
  - Conclusions
IV. Treatment
- 8. Major Nonpharmacological Treatment Modalities
  - The Goals of Treatment
  - The Treatment Process
  - Treatment Settings and Modalities
  - Psychotherapy
  - Behavioral Interventions
  - Cognitive-Behavioral Interventions
  - Other Interventions
  - Problematic Behaviors during Treatment
  - Treatment Problems of Special Populations
  - Conclusions
- 9. Pharmacological Interventions in Cocaine Abuse Treatment
  - Strategies Underlying Pharmacological Treatment
  - Agents Addressing Dopamine Depletion
  - Agents Addressing Attention Deficit Disorders
  - Agents Addressing Cocaine Withdrawal and Craving
  - Cocaine Antagonists (Agents Blocking Euphoria)
  - Agents Producing Aversive Reactions When Taken with Cocaine
  - Other Pharmacological Agents
  - Antiseizure Medications
  - Other Agents
  - Management of Conditions Associated with Cocaine Abuse
  - Combined Psychotherapy and Pharmacotherapy
  - NIDA Medications Development Program
  - Conclusions
- 10. Improving Treatment Outcome and Preventing Relapse
  - Evaluation of Treatment
  - Recommendations Regarding Treatment and Research
  - Relapse and Relapse Prevention
  - Conclusions
- 11. Conclusions and Recommendations
  - Treatment: What Works?
  - Special Treatment Issues
  - Research Issues
  - Societal Forces Resulting in Cocaine Use
  - Legalization
  - Treatment Policy
  - A Final Note
Notes
References
Index

Theory, Research and Treatment

Jerome J. Platt

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