Cover: Genes in Conflict: The Biology of Selfish Genetic Elements, from Harvard University PressCover: Genes in Conflict in PAPERBACK

Genes in Conflict

The Biology of Selfish Genetic Elements

Product Details


$34.50 • £30.95 • €31.95

ISBN 9780674027220

Publication Date: 03/15/2008


632 pages

6-3/8 x 9-1/4 inches

13 color illustrations, 3 halftones, 88 line illustrations, 34 tables

Belknap Press


Add to Cart

Media Requests:

Related Subjects

  • Preface
  • 1. Selfish Genetic Elements
    • Genetic Cooperation and Conflict
    • Three Ways to Achieve “Drive”
    • Within-Individual Kinship Conflicts
    • Rates of Spread
    • Effects on the Host Population
    • The Study of Selfish Genetic Elements
    • Design of This Book
  • 2. Autosomal Killers
    • The t Haplotype
      • Discovery
      • Structure of the t Haplotype
      • History and Distribution
      • Genetics of Drive
      • Importance of Mating System and Gamete Competition
      • Fate of Resistant Alleles
      • Selection for Inversions
      • Recessive Lethals in t Complexes
      • Enhancers and Suppressors
      • t and the Major Histocompatability Complex
      • Heterozygous (+/t) Fitness Effects: Sex Antagonistic?
      • Accounting for t Frequencies in Nature
    • Other Gamete Killers
      • Segregation Distorter in Drosophila
      • Spore Killers in Fungi
      • Incidence of Gamete Killers
    • Maternal-Effect Killers
      • Medea in Flour Beetles
      • HSR, scat+, and OmDDK in Mice
      • The Evolution of Maternal-Effect Killers
      • Gestational Drive?
    • Gametophyte Factors in Plants
  • 3. Selfish Sex Chromosomes
    • Sex Chromosome Drive in the Diptera
      • Killer X Chromosomes
      • Killer Y Chromosomes
      • Taxonomic Distribution of Killer Sex Chromosomes
      • Evolutionary Cycles of Sex Determination
    • Feminizing X (and Y) Chromosomes in Rodents
      • The Varying Lemming
      • The Wood Lemming
      • Other Murids
    • Other Conflicts: Sex Ratios and Mate Choice
  • 4. Genomic Imprinting
    • Imprinting and Parental Investment in Mammals
      • Igf2 and Igf2r: Oppositely Imprinted, Oppositely Acting Growth Factors in Mice
      • Growth Effects of Imprinted Genes in Mice and Humans
    • Evolution of the Imprinting Apparatus
      • The Mechanisms of Imprinting Involve Methylation and Are Complex
      • Conflict between Different Components of the Imprinting Machinery
      • History of Conflict Reflected in the Imprinting Apparatus
      • Evolutionary Turnover of the Imprinting Apparatus
      • Intralocus Interactions, Polar Overdominance, and Paramutation
      • Transmission Ratio Distortion at Imprinted Loci
      • Biparental Imprinting and Other Possibilities
    • Other Traits: Social Interactions after the Period of Parental Investment
      • Maternal Behavior in Mice
      • Inbreeding and Dispersal
      • Kin Recognition
      • Functional Interpretation of Tissue Effects in Chimeric Mice
      • Deceit and Selves-Deception
    • Imprinting and the Sex Chromosomes
    • Genomic Imprinting in Other Taxa
      • Flowering Plants
      • Other Taxa Predicted To Have Imprinting
  • 5. Selfish Mitochondrial DNA
    • Mitochondrial Genomics: A Primer
    • Mitochondrial Selection within the Individual
      • “Petite” Mutations in Yeast
      • Within-Individual Selection and the Evolution of Uniparental Inheritance
      • Within-Individual Selection under Uniparental Inheritance
      • DUI: Mother-to-Daughter and Father-to-Son mtDNA Inheritance in Mussels
    • Cytoplasmic Male Sterility
      • Uniparental Inheritance Implies Unisexual Selection
      • Disproportionate Role of mtDNA in Plant Male Sterility
      • Mechanisms of Mitochondrial Action and Nuclear Reaction
      • CMS and Restorers in Natural Populations
      • CMS, Masculinization, and the Evolution of Separate Sexes
      • Pollen Limitation, Frequency Dependence, and Local Extinction
      • Resource Reallocation versus Inbreeding Avoidance
      • Importance of Mutational Variation
      • CMS and Paternal Transmission
    • Other Traces of Mito-Nuclear Conflict
      • Mitochondria and Apoptosis
      • Mitochondria and Germ Cell Determination
      • Mitochondria and RNA Editing
  • 6. Gene Conversion and Homing
    • Biased Gene Conversion
      • Molecular Mechanisms
      • Effective Selection Coefficients due to BGC in Fungi
      • BGC and Genome Evolution
      • BGC and Evolution of the Meiotic Machinery
    • Homing and Retrohoming
      • How HEGs Home
      • HEGs Usually Associated with Self-Splicing Introns or Inteins
      • HEGs and Host Mating System
      • Evolutionary Cycle of Horizontal Transmission, Degeneration, and Loss
      • HEG Domestication and Mating-Type Switching in Yeast
      • Group II Introns
    • Artificial HEGs as Tools for Population Genetic Engineering
      • The Basic Construct
      • Increasing the Load
      • Preventing Natural Resistance and Horizontal Transmission
      • Population Genetic Engineering
      • Other Uses
  • 7. Transposable Elements
    • Molecular Structure and Mechanisms
      • DNA Transposons
      • LINEs and SINEs
      • LTR Retroelements
    • Population Biology and Natural Selection
      • Transposition Rates Low but Greater than Excision Rates
      • Natural Selection on the Host Slows the Spread of Transposable Elements
      • Rapid Spread of P Elements in D. melanogaster
      • Net Reproductive Rate a Function of Transposition Rate and Effect on Host Fitness
      • Reducing Harm to the Host
      • Transposition Rate and Copy Number “Regulation”
      • Selection for Self-Recognition
      • Defective and Repressor Elements
      • Extinction of Active Elements in Host Species
      • Horizontal Transmission and Long-Term Persistence
      • Transposable Elements in Inbred and Outcrossed Populations
      • Beneficial Inserts
      • Rates of Fixation
    • Transposable Elements and Host Evolution
      • Transposable Elements and Chromosomal Rearrangements
      • Transposable Elements and Genome Size
      • Co-Option of Transposable Element Functions and Host Defenses
      • Transposable Elements as Parasites, Not Host Adaptations or Mutualists
    • Origins
      • Ancient, Chimeric, and Polyphyletic Origins
  • 8. Female Drive
    • Selfish Centromeres and Female Meiosis
      • Abnormal Chromosome 10 of Maize
      • Other Knobs in Maize
      • Deleterious Effects of Knobs in Maize
      • Knobs, Supernumerary Segments, and Neocentromeres in Other Species
      • Meiosis-Specific Centromeres and Holocentric Chromosomes
      • Selfish Centromeres and Meiosis I
      • The Importance of Centromere Number: Robertsonian Translocations in Mammals
      • Sperm-Dependent Female Drive?
    • Female Drive and Karyotype Evolution
    • Polar Bodies Rejoining the Germline
  • 9. B Chromosomes
    • Drive
      • Types of Drive
      • Genetics of A and B Factors Affecting B Drive
      • Transmission Rates in Well-Studied Species
      • Absence of Drive
      • Degree of Outcrossing and Drive
    • Effects on the Phenotype
      • Effects on Genome Size, Cell Size, and Cell Cycle
      • Effects on the External Phenotype
      • Disappearance from Somatic Tissue
      • B Number and the Odd-Even Effect
      • Negative Effects of Bs More Pronounced under Harsher Conditions
      • Is the Sex of Drive Associated with the Sex of Phenotypic Effect?
      • B Effects on Recombination Among the As
      • Pairing of A Chromosomes in Hybrids
    • Neutral and Beneficial Bs
      • Beneficial B Chromosomes
      • B Chromosomes in Eyprepocnemis plorans: A Case of Continuous Neutralization?
    • Structure and Content
      • Size
      • Polymorphism
      • Heterochromatin
      • Genes
      • Tandem Repeats
    • The Origin of Bs
    • A Factors Associated with B Presence
      • Genome Size
      • Chromosome Number
      • Ploidy
      • Shape of A Chromosomes
    • Bs and the Sex Ratio
      • Paternal Sex Ratio (PSR) in Nasonia
      • X–B Associations in Orthoptera
      • Has the Drosophila Y Evolved from a B?
      • Other Effects of Bs on the Sex Ratio
      • Male Sterility in Plantago
  • 10. Genomic Exclusion
    • Paternal Genome Loss in Males, or Parahaplodiploidy
      • PGL in Mites
      • PGL in Scale Insects
      • PGL in the Coffee Borer Beetle
      • PGL in Springtails?
      • Evolution of PGL
      • PGL and Haplodiploidy
    • Sciarid Chromosome System
      • Notable Features of the Sciarid System
      • An Evolutionary Hypothesis
      • Mechanisms
      • PGL in Gall Midges
    • Hybridogenesis, or Hemiclonal Reproduction
      • The Topminnow Poeciliopsis
      • The Water Frog Rana esculenta
      • The Stick Insect Bacillus rossius-grandii
      • Evolution of Hybridogenesis
    • Androgenesis, or Maternal Genome Loss
      • The Conifer Cupressus dupreziana
      • The Clam Corbicula
      • The Stick Insect Bacillus rossius-grandii
  • 11. Selfish Cell Lineages
    • Mosaics
      • Somatic Cell Lineage Selection: Cancer and the Adaptive Immune System
      • Cell Lineage Selection in the Germline
      • Evolution of the Germline
      • Selfish Genes and Germline-Limited DNA
    • Chimeras
      • Taxonomic Survey of Chimerism
      • Somatic Chimerism and Polar Bodies
  • 12. Summary and Future Directions
    • Logic of Selfish Genetic Elements
    • Molecular Genetics
    • Selfish Genes and Sex
    • Fate of a Selfish Gene within a Species
    • Movement between Species
    • Distribution among Species
    • Role in Host Evolution
    • The Hidden World of Selfish Genetic Elements
  • References
  • Glossary
  • Index

Awards & Accolades

  • Robert Trivers Is Winner of the 2007 Crafoord Prize in Biosciences

Share This

Murty Classical Library of India

Recent News

Black lives matter. Black voices matter. A statement from HUP »

From Our Blog

Photograph of the book Fearless Women against red/white striped background

A Conversation with Elizabeth Cobbs about Fearless Women

For Women’s History Month, we are highlighting the work of Elizabeth Cobbs, whose new book Fearless Women shows how the movement for women’s rights has been deeply entwined with the history of the United States since its founding. Cobbs traces the lives of pathbreaking women who, inspired by American ideals, fought for the cause in their own ways