Cover: The Double Helix and the Law of Evidence, from Harvard University PressCover: The Double Helix and the Law of Evidence in HARDCOVER

The Double Helix and the Law of Evidence

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Product Details


$60.50 • £48.95 • €54.50

ISBN 9780674035881

Publication Date: 01/01/2010


352 pages

6-1/8 x 9-1/4 inches

5 halftones, 5 line illustrations


  • List of Figures*
  • Preface
  • Acknowledgments
  • Introduction
  • 1. Before DNA: Genetic Markers
    • Immunogenetics of the ABO Group
    • Is the Theory Generally Accepted?
    • More Immunogenetic Markers
    • The Thin-Gel-Multisystem Controversy
  • 2. Trial by Mathematics
    • Inclusions versus Exclusions
    • The Admissibility of Percentages and Probabilities
  • 3. The Dawn of DNA Typing
    • Genes, Chromosomes, DNA, and Sex
    • From Protein Polymorphisms to Restriction Fragment Length Polymorphisms
    • Restriction Fragment Length Polymorphisms
    • Multilocus Variable Number Tandem Repeat Probes
    • The Probability of Individuality
    • Forensic Applications
    • DNA Evidence circa 1986
  • 4. The Emergence of VNTR Profiling
    • Into the Courtroom
    • The Double Murder and the Handyman
    • The Pretrial Hearing
    • The Aftermath
    • Castro’s Progeny
  • 5. The Intensifying Debate over Probability and Population Genetics
    • The Aversion to Numbers
    • The Validity of the Numbers
    • The Match Window
    • Allele Frequencies
    • The Basic Product Rule for Combining Allele Frequencies
    • Threats to Independence
    • The Lewontin-Hartl Article
    • The National Research Council Speaks
  • 6. The Initial Reaction to the 1992 NRC Report
    • The Initial Reception of the NRC Report in the Courts
    • Hitting the Ceiling
    • Evaluating the Population-Genetics Debate
  • 7. Ending the Debate over Population Genetics
    • Lobbying the Academy
    • The NRC Speaks Again
    • Simpson Meets His Match
    • Boodles and Louder
    • The Second NRC Report in the Courts
  • 8. Moving Back to Errors and Relatives
    • Proficiency Testing and Error Rates
    • The Evil Twin and Other Relatives
  • 9. Moving On to Short Tandem Repeat Loci
    • The Polymerase Chain Reaction
    • Early PCR-Based Discrete-Allele Systems
    • More PCR-Based Systems: Short Tandem Repeats and Alphabet Soup
  • 10. Transcending Race and Unscrambling Mixed Stains
    • Deracializing DNA Statistics
    • Unscrambling Mixtures
  • 11. Outside the Nucleus: Mitochondrial DNA
    • The Ordeal of Clara and Emmanuel Rojas
    • The Ghost of Corleone
    • The Last Tsar
  • 12. Stray Hairs
    • Ware’s Hair
    • Saving Simpson’s Scalp
    • A Connecticut Yankee in Court
    • An Experiment in Delaware
  • 13. Learning from DNA
    • Payment
    • Selection and Cultivation
    • Exposure
    • Neutral Expertise
    • Other Reforms
  • Appendix: Timeline of Selected Developments in or Affecting Forensic Genetics
  • Notes
  • References
  • Cases and Statutes
  • Index
  • * Figures:
    • 3.1 Two ways of representing the DNA double helix
    • 3.2 Experiment detects a DNA allele with restriction sites 3.2 kb apart by producing a radioactively tagged 3.2 kb restriction fragment
    • 3.3 Experiment detects a DNA allele with an interior restriction site by producing a tagged 1.2 kb fragment
    • 3.4 Sketch of an RFLP autorad indicative of a SNP
    • 3.5 Schematic diagram of a VNTR locus
    • 3.6 Jeffreys’s autoradiograph of the first “DNA fingerprints”
    • 4.1 Autoradiograph of restriction fragment length alleles from many loci in seventeen individuals obtained with the 33.15 multilocus probe
    • 4.2 Autoradiograph of restriction fragment length alleles at the D2S44 locus for twelve individuals obtained with a single-locus probe
    • 9.1 Sketch of an electropherogram for two D16 alleles
    • 9.2 Alleles of fifteen STR loci and the amelogenin sex-typing test from the AmpFISTR Identifiler kit

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