Cover: The Variation and Adaptive Expression of Antibodies, from Harvard University PressCover: The Variation and Adaptive Expression of Antibodies in E-DITION

The Variation and Adaptive Expression of Antibodies

Available from De Gruyter »

Product Details

E-DITION

$65.00 • £54.95 • €60.00

ISBN 9780674365148

Publication Date: 01/01/1973

219 pages

World

Harvard University Press has partnered with De Gruyter to make available for sale worldwide virtually all in-copyright HUP books that had become unavailable since their original publication. The 2,800 titles in the “e-ditions” program can be purchased individually as PDF eBooks or as hardcover reprint (“print-on-demand”) editions via the “Available from De Gruyter” link above. They are also available to institutions in ten separate subject-area packages that reflect the entire spectrum of the Press’s catalog. More about the E-ditions Program »

During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics.

Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well.

Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system’s most important peculiarities.

Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics.

This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.

From Our Blog

Jacket: The Idealist: Wendell Willkie’s Wartime Quest to Build One World, by Samuel Zipp, from Harvard University Press

Q&A with Samuel Zipp, author of The Idealist: Wendell Willkie’s Wartime Quest to Build One World

Debates about what should be America’s role in the world are not new—neither is the slogan “America First.” So as the presidential election nears, we spoke with Samuel Zipp, whose book, The Idealist: Wendell Willkie’s Wartime Quest to Build One World, is a dramatic account of the former Republican presidential nominee’s worldwide plane trip