Cover: The Variation and Adaptive Expression of Antibodies, from Harvard University PressCover: The Variation and Adaptive Expression of Antibodies in E-DITION

The Variation and Adaptive Expression of Antibodies

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$65.00 • £54.95 • €60.00

ISBN 9780674365148

Publication Date: 01/01/1973

219 pages


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  • 1. Introduction to the Immune Response
    • Preadaptive Immunocompetence and the Central Problem of Immunity
    • The Problem of Antibody Diversity
    • The Number of Antibodies
  • 2. The Basic Structure of Immunoglobulins
  • 3. Reconstructing Protein Evolution
    • The Method of Minimum Mutations
    • The Method of Fitch and Margoliash
    • Limitations of Reconstruction Methods
  • 4. The Evolution of C Regions
    • CL Evolution
    • CH Evolution
  • 5. Theories of Antibody Diversity
    • The Simple Translational Theory
    • The Somatic Mutation Theory
    • The Germline Theory: The Problem of Selection in Antibodies
    • The Somatic Recombination Theory
  • 6. The Evolution of V Regions: The Case for the Germline Theory
    • Expectations of Theories of Antibody Diversity
    • The Evolution of Vκ Regions
    • The Evolution of Vλ Regions
    • The Evolution of VH Regions
    • The Meaning of Sequence Identities
    • Conclusions
    • DNA-RNA Hybridization
  • 7. Species Specificity and Allotypes in V Regions: Evidence against the Germline Theory
    • Species Specificity in V Regions
    • Rabbit VH Allotypes
  • 8. The Clonal Selection Theory
    • Evidence Pertaining to the Clonal Selection Theory
    • Recommitment of Cells from IgM to IgG
    • Information Transfer Experiments
  • 9. The Joining of V and C Regions: Theories of Cell Commitment
    • Theories of Joining and Commitment
    • The Pattern of Variation at the V-C Junction of κ Chains
    • Programmed Gene Translocations and Differentiation
  • Appendix A Properties and Provenances of Immunoglobulin Sequences
  • Appendix B Immunoglobulin Allotypes
  • Appendix C The Ribosomal RNA Genes
  • References
  • Index

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