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- 1. Introduction to the Immune Response
- Preadaptive Immunocompetence and the Central Problem of Immunity
- The Problem of Antibody Diversity
- The Number of Antibodies
- 2. The Basic Structure of Immunoglobulins
- 3. Reconstructing Protein Evolution
- The Method of Minimum Mutations
- The Method of Fitch and Margoliash
- Limitations of Reconstruction Methods
- 4. The Evolution of C Regions
- CL Evolution
- CH Evolution
- 5. Theories of Antibody Diversity
- The Simple Translational Theory
- The Somatic Mutation Theory
- The Germline Theory: The Problem of Selection in Antibodies
- The Somatic Recombination Theory
- 6. The Evolution of V Regions: The Case for the Germline Theory
- Expectations of Theories of Antibody Diversity
- The Evolution of Vκ Regions
- The Evolution of Vλ Regions
- The Evolution of VH Regions
- The Meaning of Sequence Identities
- Conclusions
- DNA-RNA Hybridization
- 7. Species Specificity and Allotypes in V Regions: Evidence against the Germline Theory
- Species Specificity in V Regions
- Rabbit VH Allotypes
- 8. The Clonal Selection Theory
- Evidence Pertaining to the Clonal Selection Theory
- Recommitment of Cells from IgM to IgG
- Information Transfer Experiments
- 9. The Joining of V and C Regions: Theories of Cell Commitment
- Theories of Joining and Commitment
- The Pattern of Variation at the V-C Junction of κ Chains
- Programmed Gene Translocations and Differentiation
- Appendix A Properties and Provenances of Immunoglobulin Sequences
- Appendix B Immunoglobulin Allotypes
- Appendix C The Ribosomal RNA Genes
- References
- Index
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