Cover: Brainstorming: The Science and Politics of Opiate Research, from Harvard University PressCover: Brainstorming in E-DITION


The Science and Politics of Opiate Research

Available from De Gruyter »

Product Details


$65.00 • €48.00

ISBN 9780674366015

Publication Date: 09/09/1989

208 pages



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  • Prologue
  • 1. The Politics of Science
    • Nixon’s War on Heroin
    • Letter to the White House
    • Drug-Abuse Research Centers Announced
    • Grantsmanship
  • 2. Drug Wars
    • Opium Among the Ancients
    • Product Development in the Renaissance
    • From Use to Abuse
    • Patent Medicine, an American Business
    • The China Connection
    • The Harrison Narcotic Act
  • 3. Stalking the Opiate Receptor
    • Emergence of the Receptor Concept
    • Potency
    • Evidence from Antagonists
    • Mirror Images
    • Binding Experiments
    • Goldstein’s Forays
    • Clues from Insulin
    • First Failures
    • Breakthrough
  • 4. Staking the Claim and Taking the Blame
    • Writing It Up
    • Playing Checkers with the White House
    • Meet the Press
    • Who’s on First?
    • Competition at Home and Abroad
    • On the Boardwalk
  • 5. Agonists and Antagonists
    • Mixed Blessings
    • Enter the Drug Companies
    • Aversion Therapy
    • Dividing the Spoils
    • The Sodium Effect
    • Pain and Euphoria
    • Visualizing Opiate Receptors
  • 6. The Brain’s Own Morphine
    • False Starts
    • Surprise from Scotland
    • Brookline, May 1974
    • The Race Is On
  • 7. The Name Game
    • Cornering the Market on Calf Brains
    • Agu’s Rats
    • Isolating It
    • Scooped
    • Naming the Baby
  • 8. Designer Drugs
    • Hope for Chronic Pain Relief
    • Patent Disputes and Litigation
    • Enkephalin Derivatives Fail
    • Back to Basics
    • Resurrecting Endorphins
    • It’s All Greek to Me
    • Endorphins, Stress, and the Immune Response
  • 9. From Opiates to Schizophrenia
    • Nietzsche and the NIH
    • Shattered Minds
    • Molecular Models
    • Identifying Dopamine Receptors
    • Amphetamine Psychosis
    • A Dopamine Concept of Schizophrenia
    • Locating Schizophrenia in the Brain
  • 10. Receptivity
    • Dawning of the Receptor Era
    • On the Horizon
    • Who Will Make the Discoveries?
  • Notes
  • Acknowledgments
  • Index

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