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Goitrous patients in the Argentina area form the subject of this book. The authors have tried to define in quantitative terms the adaptive changes that occur when the thyroid gland seeks to compensate for iodine deficiency. In addition, the metabolism of iodine as disclosed by studies with radioactive iodine has been examined in detail. An attempt has been made to give a thorough account of the dynamic processes involved in thyroid-hormone synthesis and secretion and the factors that govern the rate constants involved. Finally, future areas of productive research suggested by the studies that were done have been outlined.