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Asserting that clinical practice should rest on sound scientific theory and research, Dr. J. H. Means discusses the life story of the thyroid hormone. He explains the integrative action of the endocrine system, the elaboration of the thyroid hormone, and the significance of its structure and of its action in end organs. The use of hormones, drugs, and radiation in the management of thyroid diseases is the central problem of the book. The author continues with an exploration of the etiology of Graves’s disease, and he concludes with a section devoted to the needs for iodine. The relation of the pituitary gland to the function of the thyroid is thoroughly covered.