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The coagulabihty of the blood is a phenomenon that has tantalized scientists throughout history. This is the first approach to blood coagulation as a unified subject with prothrombin as the major theme.
The fundamental methodology involves the preparation of purified biological reagents such as prothrombin, and the study of their “activation” under standardized conditions, including simple chemical and complex biological activities. The author views prothrombin and its derivatives as related to a series of enzymatic reactions, both in parallel and in sequence, which play a key role in major physiological mechanisms. Details lost in brief papers are included here, as well as important unpublished material.
Prothrombin is discussed at the beginning; with this basis, practical applications fall into natural order. The author’s findings and approach are significant and original; perhaps the most stimulating aspect of his book is the record of personal experience that makes the book a document in the psychology of discovery.