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This book presents an inclusive definition of rheumatoid arthritis with detailed consideration of its relation to what seem to be clinical variants and to other (probably separate) forms of joint disease. The definition and clinical description, which is both cross-sectional and longitudinal, is based on numerical studies of a large series of carefully observed and diagnosed patients. By this means the authors are able to examine the validity of previous impressions and data concerning the disease, as well as to further understanding of its clinical pattern.