Cover: Adaptive Oncogenesis: A New Understanding of How Cancer Evolves inside Us, from Harvard University PressCover: Adaptive Oncogenesis in HARDCOVER

Adaptive Oncogenesis

A New Understanding of How Cancer Evolves inside Us

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Product Details


$45.00 • £36.95 • €40.50

ISBN 9780674545397

Publication Date: 03/09/2018


288 pages

6-1/8 x 9-1/4 inches

16 line illustrations


  • Foreword [Robert A. Weinberg]
  • Introduction
  • 1. The Evolution of Life Spans and Disease Avoidance
  • 2. Understanding Evolution at Organismal and Somatic Levels
  • 3. The Evolution of Multicellularity and Tumor Suppression
  • 4. Mechanisms of Tumor Suppression
  • 5. Dominant Views of the Mechanisms of Oncogenesis
  • 6. Adaptive Oncogenesis
  • 7. Limiting Somatic Evolution in Youth
  • 8. Changing Adaptive Landscapes with Aging
  • 9. Changing Adaptive Landscapes with Carcinogenic Exposures
  • 10. Tissue Architecture and Tumor Suppression
  • 11. Peto’s Paradox
  • 12. Prolonging Tissue Maintenance to Delay Aging and Cancer
  • 13. Understanding Clinical Data from an Evolutionary Perspective
  • 14. The Causes of Cancer in Early Childhood
  • 15. Evolution-Informed Strategies to Combat Cancer
  • 16. A New Framework for Understanding and Controlling Cancer
  • References
  • Acknowledgments
  • Index

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