- 1. Oxygen and the History of Life
- The Cell’s Oxygen Sink and Energetics
- Getting Oxygen to the Sink
- Evolution of O2 Transport Systems
- Evolution of External Gas Exchangers
- Looking at the System as a Whole: Philosophy of the Approach
- 2. The Body’s Need For Oxygen
- Levels of O2 Consumption
- Estimating the Limits of O2 Consumption
- 3. Linking Structure and Function: Model, Means, and Tools
- How Does Structure Affect O2 Flow?
- Are Animals Built Reasonably?
- The Tools
- 4. Cell Respiration
- Gaining Energy from Combustion
- Metabolic Pathways of the Cell
- The Cell’s Energetic Balance Sheet
- 5. Mitochondria: The Cell’s Furnaces
- Putting Some Order into Cell Metabolism
- Oxidation–Phosphorylation Coupling Depends on Structure
- Mitochondria and the Cell’s Aerobic Potential
- Mitochondria in Muscle Cells
- 6. The Vehicle For Oxygen Transport: Blood and Circulation
- The O2 and CO2 Carrier: Blood
- Moving Blood Around: Circulation
- O2 Transport by the Blood
- 7. Delivering Oxygen to the Cells
- Distributing Blood to the Tissues: Design of the Vasculature
- The Microvascular Unit
- O2 Flow from Blood to Cells
- 8. Design and Development of the Mammalian Lung
- Development of the Lung
- Lung Histogenesis: Differentiation toward Gas Exchange
- The Lung at Birth and Its Postnatal Maturation
- 9. Lung Cell Biology
- Organization of the Lung’s Cell Population
- A Closer Look at the Cells of the Gas Exchange Region
- 10. Airways and Blood Vessels
- The Airway Tree
- Ventilation
- The Vascular Trees
- Pulmonary Blood Flow
- Ventilation–Perfusion Matching
- 11. The Lung’s Mechanical Support
- External Support and Motive Force
- The Pleural Cavity
- The Lung’s Fiber Skeleton
- Surface Tension
- Micromechanics and the Configuration of the Alveolar Septum
- Keeping the Barrier Dry and Thin
- 12. The Lung as Gas Exchanger
- Design of the Gas Exchanger
- Physiological Basis for Gas Exchange
- Pulmonary Diffusing Capacity: Physiology
- Pulmonary Diffusing Capacity: Morphometry
- Structure and Function Compared
- Matching the Conductance to O2 Needs: The Emergence of a Paradox
- Resolving the Paradox: Models and Nature
- 13. The Respiratory System in Overview
- Adjusting Performance to Needs
- Adjusting Potential to Needs
- The Limits to Potential: The Smallest Mammal
- Units of Measurement
- General References
- Index
The Pathway for Oxygen
Structure and Function in the Mammalian Respiratory System
Product Details
PAPERBACK
$52.00 • £45.95 • €47.95
ISBN 9780674657908
Publication Date: 01/01/1984
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