Cover: Discovering Retroviruses: Beacons in the Biosphere, from Harvard University PressCover: Discovering Retroviruses in HARDCOVER

Discovering Retroviruses

Beacons in the Biosphere

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Product Details


$27.95 • £22.95 • €25.00

ISBN 9780674971707

Publication Date: 10/15/2018


192 pages

6-1/8 x 9-1/4 inches

36 color illus., 1 illus., 2 tables


  • List of Tables and Figures*
  • Introduction
  • 1. Early Pioneers
  • 2. Amending the Central Dogma
  • 3. The Origin of Retroviruses
  • 4. Retroviruses and Evolution
  • 5. Revealing the Genetic Basis of Cancer
  • 6. HIV and the AIDS Pandemic
  • Epilogue
  • Notes
  • Suggested Readings
  • Acknowledgments
  • Index
  • * Tables and Figures
    • Tables
      • 1.1. Selected Timelines for Discoveries in Genetics and Retrovirology
      • 2.1. The Retrovirus Family
      • 3.1. Major Classes of Transposable Elements in the Human Genome
    • Figures
      • 1.1. Mendel’s crosses depicted in a Punnett square
      • 1.2. Genes are encoded in DNA
      • 1.3. The Watson–Crick double helix is held together by nucleotide base pairing
      • 1.4. Semi-conservative duplication of DNA
      • 1.5. Organization of the ribosome
      • 1.6. Transcription of messenger RNA from genes in DNA
      • 1.7. The genetic code
      • 1.8. Translation of messenger RNA (mRNA) into protein
      • 2.1. Serial dilutions of a virus preparation and the bacteriophage plaque assay
      • 2.2. Plate assays for animal viruses
      • 2.3. Retroviral DNA synthesis and its integration into host DNA
      • 2.4. Particle architecture and genome organization of the prototype avian leukosis virus
      • 2.5. Reproduction cycle of the prototype avian leukosis virus in a host cell
      • 3.1. The Miller–Urey apparatus
      • 3.2. Self-splicing by the Tetrahymena ribozyme
      • 3.3. Successive steps in the transition from an RNA world to a DNA world
      • 3.4. The tree of life
      • 3.5. The retrotransposons
      • 3.6. Propagation of L1 LINE retrotransposons
      • 3.7. Telomeres are formed by addition of repeated sequences to chromosome ends via reverse transcription
      • 4.1. Nucleic acid hybridization
      • 4.2. Estimating the age of endogenous retroviruses from an evolutionary tree
      • 4.3. Endogenous retroviral DNA recombination induces host gene shuffling
      • 4.4. Regulatory sequences in the LTRs of endogenous retroviruses can affect host gene expression
      • 4.5. Splicing signals in HERVs can lead to altered cell messenger RNA production and abnormal protein formation
      • 4.6. The host-virus evolutionary arms race
      • 5.1. Isolation of a src probe by subtractive hybridization
      • 5.2. Signal transduction
      • 5.3. Origin of transducing retroviruses
      • 5.4. Major lymphocytes of the adaptive immune system
      • 5.5. HTLV-I provirus and genes encoding viral oncoproteins
      • 6.1. HIV antibody assay provides the first blood screen
      • 6.2. Cradle of the AIDS pandemic
      • 6.3. HIV-1 origins via cross-species transmissions of SIV
      • 6.4. Regulatory and auxiliary proteins encoded in the HIV-1 genome
      • 6.5. Life-sparing effect of HIV antiviral treatment

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