- Introduction
- 1. Obligate Parasites of Cells
- The Virosphere and Its Metagenome
- Complexity and “Dark Matter”
- Selfish Information and the Essence of Being Viral
- The Emergence of Egotistical Replicators
- The Viral Empire
- 2. Viruses, Genes, and Ecosystems
- Lifestyles and Life Cycles
- Lysogeny: Exercising Temperance
- Kill the Winner
- Gene Brokers
- Selfishness Drives Adaptive Evolution
- Phages and the Microbiome
- Unfriendly Competition
- Chemical Warfare
- 3. Potentiation of Bacterial Diseases by Phages
- For a Charm of Powerful Trouble
- Toxic Enablers
- Choose Your Poison
- Treasure Islands
- Prophage Induction and Antibiotic Drug Resistance
- 4. Viruses and Higher Organisms
- Viruses, Cells, Organisms, and Populations
- “Just a Virus”
- Human Rhinoviruses
- Uncommon Diversity
- Accidents of Pathogenesis
- Mutation, Diversity, and Quasipecies
- 5. The Flu: No Common Cold
- Antigenic Escape Artists
- Human Influenza A Virus
- Epidemic Influenza: Dress for the Season
- Quasispecies, Sequence Clusters, and Codon Bias
- Correlating Genetic and Antigenic Evolution
- Seeding of Seasonal Epidemics
- Pandemic Influenza: The Emperor with No Clothes
- 6. Alternative Virus Lifestyles
- Latency: Till Death Do Us Part
- All in the Family Herpesviridae
- 7. Evolutionary Mechanisms of DNA Viruses
- Gene Duplication and Gene Capture
- Poxvirus Evolution
- Poxvirus Party Tricks
- Small DNA Virus Evolution
- 8. Viroids and Megaviruses: Extremes
- Viroids: The Smallest
- Evolutionary Reliquary
- Megaviruses: The Biggest
- Big and Bigger
- Virophages: Fleas upon Fleas
- Chimerism
- Megavirus Origins: Mavericks at Heart
- 9. HIV-1: A Very Modern Pandemic
- A New Disease and a New Virus
- Anatomy of HIV-1
- HIV in the Making
- Socioepidemiology of AIDS: A Man-Made Epidemic
- Within-Host Evolution: A Very Personal Arms Race
- Shortsighted Evolution
- Adaptive Evolution: An Evolving Relationship
- Outrunning the Red Queen
- Medicine at the Virus–Host Interface
- Resistance Is Futile
- 10. Cross-Species Infections: Means and Opportunity
- A Rogue’s Gallery of Emerging Viruses
- Adaptive Evolution in Zoonosis
- Fitness Landscape
- A Shifting Fitness Landscape
- The Paradox in RNA Virus Evolution
- RNA Viruses and Molecular Clocks
- Arboviruses: Vector-Borne Viruses
- Evolutionary Compromise
- Host Restriction
- 11. Future Pandemic Influenza: Enemy at the Gates
- Real and Present Danger
- Pandemic Threat Level
- The Pandemic Phenotype
- Outbreak
- 12. Ebolavirus
- EBOV Makona
- What We Were Afraid to Say about Ebola
- Evolution or Adaptive Change
- EBOV Persistence
- 13. Viral Zoonoses and Animal Reservoirs
- The Usual Suspects
- Filovirus Origins
- Bats and Viral Zoonoses
- A Special Relationship
- Tolerance and Resistance
- 14. Endogenous Retroviruses: Our Viral Heritage
- Genome Invasion by Retroviruses
- Endogenization in Progress
- Change Agents
- Domestication of ERV Genes
- Endogenous Viral Elements
- 15. Viruses as Human Tools
- Myxoma Virus: Biological Control
- Genomics of an Attenuated Poxvirus
- Orthopoxviruses: Past Solutions and Future Problems
- Live-Attenuated Viruses
- Attenuation by Design
- Virus Therapeutics
- Doctor’s Little Helpers
- Oncolytic Viruses
- 16. Conclusion: Humanity and Viruses
- The Human Future and Viruses
- Beauty in Design
- References
- Acknowledgments
- Index
Viruses
Agents of Evolutionary Invention
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Product Details
HARDCOVER
$51.50 • £41.95 • €46.50
ISBN 9780674972087
Publication Date: 06/19/2017
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