Cover: Viruses: Agents of Evolutionary Invention, from Harvard University PressCover: Viruses in HARDCOVER

Viruses

Agents of Evolutionary Invention

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Product Details

HARDCOVER

$51.50 • £41.95 • €46.50

ISBN 9780674972087

Publication Date: 06/19/2017

Text

384 pages

6-1/8 x 9-1/4 inches

World

  • Introduction
  • 1. Obligate Parasites of Cells
    • The Virosphere and Its Metagenome
    • Complexity and “Dark Matter”
    • Selfish Information and the Essence of Being Viral
    • The Emergence of Egotistical Replicators
    • The Viral Empire
  • 2. Viruses, Genes, and Ecosystems
    • Lifestyles and Life Cycles
    • Lysogeny: Exercising Temperance
    • Kill the Winner
    • Gene Brokers
    • Selfishness Drives Adaptive Evolution
    • Phages and the Microbiome
    • Unfriendly Competition
    • Chemical Warfare
  • 3. Potentiation of Bacterial Diseases by Phages
    • For a Charm of Powerful Trouble
    • Toxic Enablers
    • Choose Your Poison
    • Treasure Islands
    • Prophage Induction and Antibiotic Drug Resistance
  • 4. Viruses and Higher Organisms
    • Viruses, Cells, Organisms, and Populations
    • “Just a Virus”
    • Human Rhinoviruses
    • Uncommon Diversity
    • Accidents of Pathogenesis
    • Mutation, Diversity, and Quasipecies
  • 5. The Flu: No Common Cold
    • Antigenic Escape Artists
    • Human Influenza A Virus
    • Epidemic Influenza: Dress for the Season
    • Quasispecies, Sequence Clusters, and Codon Bias
    • Correlating Genetic and Antigenic Evolution
    • Seeding of Seasonal Epidemics
    • Pandemic Influenza: The Emperor with No Clothes
  • 6. Alternative Virus Lifestyles
    • Latency: Till Death Do Us Part
    • All in the Family Herpesviridae
  • 7. Evolutionary Mechanisms of DNA Viruses
    • Gene Duplication and Gene Capture
    • Poxvirus Evolution
    • Poxvirus Party Tricks
    • Small DNA Virus Evolution
  • 8. Viroids and Megaviruses: Extremes
    • Viroids: The Smallest
    • Evolutionary Reliquary
    • Megaviruses: The Biggest
    • Big and Bigger
    • Virophages: Fleas upon Fleas
    • Chimerism
    • Megavirus Origins: Mavericks at Heart
  • 9. HIV-1: A Very Modern Pandemic
    • A New Disease and a New Virus
    • Anatomy of HIV-1
    • HIV in the Making
    • Socioepidemiology of AIDS: A Man-Made Epidemic
    • Within-Host Evolution: A Very Personal Arms Race
    • Shortsighted Evolution
    • Adaptive Evolution: An Evolving Relationship
    • Outrunning the Red Queen
    • Medicine at the Virus–Host Interface
    • Resistance Is Futile
  • 10. Cross-Species Infections: Means and Opportunity
    • A Rogue’s Gallery of Emerging Viruses
    • Adaptive Evolution in Zoonosis
    • Fitness Landscape
    • A Shifting Fitness Landscape
    • The Paradox in RNA Virus Evolution
    • RNA Viruses and Molecular Clocks
    • Arboviruses: Vector-Borne Viruses
    • Evolutionary Compromise
    • Host Restriction
  • 11. Future Pandemic Influenza: Enemy at the Gates
    • Real and Present Danger
    • Pandemic Threat Level
    • The Pandemic Phenotype
    • Outbreak
  • 12. Ebolavirus
    • EBOV Makona
    • What We Were Afraid to Say about Ebola
    • Evolution or Adaptive Change
    • EBOV Persistence
  • 13. Viral Zoonoses and Animal Reservoirs
    • The Usual Suspects
    • Filovirus Origins
    • Bats and Viral Zoonoses
    • A Special Relationship
    • Tolerance and Resistance
  • 14. Endogenous Retroviruses: Our Viral Heritage
    • Genome Invasion by Retroviruses
    • Endogenization in Progress
    • Change Agents
    • Domestication of ERV Genes
    • Endogenous Viral Elements
  • 15. Viruses as Human Tools
    • Myxoma Virus: Biological Control
    • Genomics of an Attenuated Poxvirus
    • Orthopoxviruses: Past Solutions and Future Problems
    • Live-Attenuated Viruses
    • Attenuation by Design
    • Virus Therapeutics
    • Doctor’s Little Helpers
    • Oncolytic Viruses
  • 16. Conclusion: Humanity and Viruses
    • The Human Future and Viruses
    • Beauty in Design
  • References
  • Acknowledgments
  • Index

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